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A weight loss greater than 10% (therapeutic target in NAFLD) was achieved in 70.9% of semaglutide-treated patients and 25.6% of liraglutide-treated patients, with comparable rates of gastrointestinal adverse events [46]

The duration varies depending on individual goals, progress, and health conditions, but long-term safety and effectiveness have been supported by multiple clinical studies

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While it is possible to generate and screen larger cyclic peptide rings with more randomized amino acid positions, the size of such a library would still be limited by the transformation efficiency of the host organism