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For instance, the presence of glucose in the small intestine induces the release of serotonin and GLP1, which activates vagal afferents in the intestinal mucosa, resulting in the regulation of gastric emptying, pancreatic exocrine and intestinal fluid secretion (Raybould, 2010)
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In PIONEER 6 trial, 3183 patients with T2DM were randomized to either oral semaglutide or placebo were observed for cardiovascular events up to a median of approximately 16 months
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