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The main ingredient in most GLP-1 patches is berberine, a plant-derived substance, along with other herbal supplements.While some of these ingredients may lead to modest weight loss (1-3 pounds) when taken orally, there is no scientific evidence supporting their effectiveness when delivered through the skin

Peer review Peer review information Nature Medicine thanks Johnny Ludvigsson, Judy Zhong and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

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