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References CVS Caremark

The change in body weight, fat mass, and lean mass from baseline to week 72 was 21.3 percent, 33.9 percent, and 10.9 percent respectively with tirzepatide

Recommended Dosage in Patients with Severe Renal Impairment (eGFR of 15 to 29 mL/min/1.73 m 2) Adults and Pediatric Patients Aged 4 Years and Older with Acquired HO IMCIVREE is not recommended for use in adults and pediatric patients aged 4 years and older with acquired HO and severe renal impairment

More serious potential risks include gallbladder disease and acute pancreatitis (seek urgent medical attention for severe, persistent abdominal pain radiating to the back)