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A 2026 review in Drugs lays out the clinical tension clearly: maternal obesity + excess gestational weight gain drive major short- and long-term risks for both mother and baby, while lifestyle-only strategies often deliver modest resultscreating a real unmet need

Additionally, the loss of fatty acids can affect the skin barrier, leading to dryness and a lacklustre appearance

This paper provides a review on the current evidence supporting the use of GLP-1 in experimental animal models and human trials with the ischemic and non-ischemic heart and discusses their molecular mechanisms and potential as a new therapeutic approach.