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doi: 10.1016/j.arr.2019.100936

Here is the most important takeaway: As of late 2025, there are no FDA-approved GLP-1 medication patches (semaglutide, tirzepatide, or others) commercially available from a legitimate pharmacy
Several mechanisms explain why GLP-1 RAs reduce body weight: Central appetite suppression: GLP-1 receptors in the hypothalamus and brainstem alter hunger signalling and food reward

Nature 509 , 183188 (2014)
