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Two medications leading this revolution are semaglutide (marketed as Ozempic and Wegovy) and tirzepatide (marketed as Mounjaro and Zepbound)

Proc Natl Acad Sci USA 80:54855489

Headaches often emerge during dose escalation phases, suggesting a relationship with medication titration

Nonetheless, GLP-1RA is known to affect the intestinal environment and, indeed, changes in the gut microbiota have been linked to GLP-1RAs 26,27,28
