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These benefits likely arise through a combination of weight-mediated and weight-independent mechanisms, including natriuresis, improved vascular function, and autonomic modulation

The natriuretic and diuretic effect of GLP-1R agonism was first shown in 1996 [92] and was subsequently confirmed in rodents [642,660,761] and in healthy, obese, and type-2 diabetic humans [661,663]

A new Biological Psychiatry review sharpens the case that GLP-1 drugs may affect addiction through brain reward circuits, not simply by reducing appetite