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When meals include protein, fiber, and fat alongside carbs digestion slows, blood sugar stabilizes, and GLP-1 production increases

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In trials (DURATION program), once-weekly exenatide 2 mg showed slightly more A1c reduction (~1.5% drop from baseline 8.3%) than Byetta BID (~1.0% drop) with fewer GI side effects after initial weeks ( [6] )

But given just how miraculous semaglutide is for obesity, and given the miraculous anecdotes , I dont see how to spin this paper as anything but a letdown