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(3) attenuation of hepatic fat deposition and suppression of hepatic stellate cell activation

Investigating the underlying molecular mechanisms, Tirzepatide was found to activate critical intracellular signaling pathways

For functional enrichment analysis, enriched gene sets were determined by applying the same workflow used for RNA, using the R package gprofiler2 (v.0.2.0)

For those with multiple chronic conditions, complex medication regimens, or clinical situations that warrant a more comprehensive workup before initiating GLP-1 therapy, a traditional relationship with an obesity medicine specialist or endocrinologist may provide a better level of oversight