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For symptom management of neuropathic pain, the American Academy of Neurology and American Diabetes Association guidelines recommend: First-line: Duloxetine or pregabalin (with appropriate renal dose adjustments) Alternative options: Gabapentin (with renal dose adjustments) or tricyclic antidepressants (with caution in older adults and cardiac disease) Topical treatments: Capsaicin 8% patch or lidocaine 5% patch for localized symptoms Avoid chronic opioid therapy due to limited evidence and safety concerns Non-pharmacological approaches including physical therapy, proper foot care, and pain psychology techniques provide additional benefit

If, for example, they fund more orals and multi-agonists, the medicine becomes more accessible to patient populations and it drives more demand for tech

Recent data demonstrates that GLP-1R agonizing peptide/GIPR antagonizing antibody conjugates similar to MariTide require CNS GIPR populations to drive weight loss

A patient taking a GLP-1 medication without guidance may lose weight quickly but fail to maintain muscle