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Alberto Chavez-Velazquez, an endocrinologist at the Texas Diabetes Institute who was involved in early primate research on GLP-1 drugs, noted that "although this class of medications has been on the market for decades to treat diabetes, their widespread use really took off in the last five years" and that researchers are "uncovering a trove of health benefits that extend beyond weight management." Those extended benefits are not marketing language they are documented in major clinical trials

For all three deconvolution methods, CD8+ T cells were also observed to decrease in the GLP-1R-high metastatic tissue when compared to that of GLP-1R-low tissue ( Figures 4ac )

That is why many trials choose three months as an early endpoint

Notably, the circulating glucagon-like material was also detected in 1967 by Samols and Marks in pancreatectomized humans [21] and in the following year by Roger Unger and Isabel Valverde in dogs [27]