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Any significant weight loss, regardless of method, results in some lean mass loss
GLP-1RAs reduce tumor necrosis factor-alpha (TNF-_), nuclear factor kappa B (NF-gB), interleukin (IL)-17, and IL-23 signaling

For instance, native GLP-1 infusion acutely reduced food intake in individuals without ( While GLP-1R agonism effectively reduces body weight in patients, there is a persistent need for greater efficacy of weight loss and comorbidity resolution
