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Retatrutide Phase 2 (Jastreboff et al., NEJM 2023) reported 24.2% weight loss at 48 weeks at 12 mg
Treatment Patterns Exploratory endpoints measured at EOS included the number of participants treated with oral semaglutide, semaglutide dose, and the addition or removal of glucose-lowering medications and increase or decrease in glucose-lowering medication doses
Subgroup analyses showed greater benefits in patients with prior CVD (HR 0.83) versus primary prevention (HR 0.93) [8]
