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Lancet 2006;368:1696705.ArticlePubMed 22
Both approaches significantly lowered HbA1c levels (weighted mean difference [WMD] 0.75%, 95% CI 0.97 to 0.53) but increased hypoglycemic risk [risk ratio (RR) 7.59, 95% CI 3.3517.17] compared to the unchanged GLP-1RA
That investigation has now occurred (at least in preliminary form), and the human results are more reassuring than the animal data suggested
After completion of the synthesis, the resin was transferred into a syringe with a frit, and washed three times with DMF, three times with CH 2 Cl 2 and three times with Et 2 O
