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Then they go back on the drug, and they lose weight and lose more muscle mass and the cycle continues. The yo-yo effect is one reason its so important to undergo weight-loss treatment at a comprehensive medical practice

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large Phase 3 sponsor topline results Main finding Substantial average weight reduction under trial conditions What remains unknown Full peer-reviewed Phase 3 analysis, long-term benefit-risk balance and approved patient population Type 2 diabetes Evidence available Peer-reviewed Phase 2 and Phase 3 randomized trials Main finding Improved average HbA1c and body-weight measures versus placebo in studied populations What remains unknown Regulatory conclusions, longer-term outcomes and position relative to approved treatments Knee osteoarthritis with obesity or overweight Evidence available Completed Phase 3 study with weight and pain outcomes Main finding Research examines both weight change and knee symptoms What remains unknown How much symptom change is directly attributable to weight loss, durability and any approved indication Sleep apnoea and other weight-related conditions Evidence available Phase 3 development programme Main finding Condition-specific outcomes are being tested What remains unknown Whether trials will demonstrate clinically meaningful benefit and acceptable safety Cardiovascular, kidney and liver outcomes Evidence available Ongoing or planned late-stage research Main finding Designed to test outcomes beyond body weight alone What remains unknown Long-term event data and regulator assessment What did the major trials report