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Osteoporosis was experimentally induced using a high-fat diet with streptozotocin in two studies, ovariectomy in two studies, and dexamethasone administration in one study
doi: 10.1161/CIRCRESAHA.115.306883
Regarding a potential explanation to the discrepancy in food intake reductions between studies, glucagon efficacy on satiety seems in part dependent on the state of ARC-localized CaMKK sensitivity within a GcgR/PKA/CaMKK/AMPK/AgRP axis, of which the obese state may negatively modulate [3]
They should be having blood draws for comprehensive metabolic profiles beyond just looking at labs for diabetes, he says
