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Description

Compared to baseline, DIO mice assumed phylogenetically similar gut bacterial compositional changes following liraglutide and GUB09-145 treatment, characterized by discrete shifts in low-abundant species and related bacterial metabolic pathways

The primary endpoint was the percentage weight loss at six months (M6) compared to baseline

Esophageal Ulcers located in the lower esophagus, often from reflux Causes / Risk Factors Helicobacter pylori infection (most common) NSAIDs (ibuprofen, aspirin) Excess stomach acid / hypersecretory conditions Smoking and alcohol consumption Stress (minor role) Zollinger-Ellison syndrome (gastric acidproducing tumor) Symptoms Epigastric pain (burning, gnawing, or hunger-like) Pain may improve or worsen with food: Duodenal: pain often relieved by food Gastric: pain may worsen with food Nausea / vomiting Bloating, belching Loss of appetite / weight loss Heartburn or acid reflux Warning signs (complications) Vomiting blood (hematemesis) Black, tarry stools (melena) Severe, sudden abdominal pain (possible perforation) Diagnosis Endoscopy gold standard, allows visualization and biopsy H