tirzepatide sode effects does cause loose stools TrimRX TrimRX | Side Effects of
Description
Tirzepatide has demonstrated superior efficacy in both weight loss and blood glucose control compared to semaglutide (Aronne et al., 2025), highlighting the therapeutic potential of multi-agonist strategies

Dietary modifications, adequate hydration, and gradual dose titration can help minimise gastrointestinal side effects during Mounjaro therapy
Since semaglutide is a pure agonist of the GLP-1 receptor, it exclusively stimulates the phenomena controlled by this receptor, while the ability of tirzepatide to act simultaneously on the GLP-1 and GIP receptors enables the activation of all the processes mediated by these incretins (Figure 3)

What It Means for Clinicians Continuous therapy is critical patients who maintained uninterrupted dosing experienced the greatest benefit
