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Caution is also needed in those with severe gastrointestinal disease, a history of pancreatitis, or significant psychiatric comorbidity requiring specialist input

GLP-1 receptor agonists work through several mechanisms: they enhance insulin secretion when blood glucose levels are elevated, suppress glucagon release (which reduces glucose production by the liver), slow gastric emptying, and promote satiety through effects on appetite centres in the brain

GLP-1 therapies can: Medication works best when combined with structured nutrition and activity coaching