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These strategies significantly reduce the likelihood of injection site reactions: Allow medication to reach room temperature before injecting (15-20 minutes out of the refrigerator) Rotate injection sites religiously, never repeating the same spot in consecutive weeks Inject slowly and steadily rather than pushing the plunger quickly Do not rub or massage the injection site after removing the needle Use a new, sharp needle every time, as dull needles cause more tissue trauma Clean the injection site with alcohol and let it dry completely before inserting the needle Ensure you are injecting into subcutaneous fat, not muscle If you consistently experience reactions despite following these precautions, talk to your prescribing provider

Reference List Eli Lilly and Company

Table S2 provides additional details on the instruments used to collect food- and appetite-related metrics for these studies

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