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The outer layer was made of a gelatine-polyvinyl alcohol (Gel-PVA) hydrogel, a carrier that combines good mechanical properties (gelatine provides toughness and PVA enhances strength and ensures stratum corneum penetration) 24 , stimulus responsiveness (temperature/pH), and excellent drug-carrying capability (i.e., can be loaded with hydrophobic molecules via electrostatic/hydrogen bonding)