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Finally, the analysis of adverse events suggested that high-dose oral semaglutide was associated with a higher incidence of side effects in non-Asian patients, suggesting that physicians should pay close attention to gastrointestinal side effects during treatment in non-Asian T2DM patients

The Role of Genetic Factors in GLP-1 Side Effect Tolerance Individual differences in how you respond to semaglutideincluding constipation severityare partly shaped by genetics

Willems MET, Sahin MA, Cook MD

Although several studies have reported cases of hypoglycemia associated with the use of GLP-1RAs, the main evidence available comes from clinical trials (Rolfes et al., 2015)