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The study employed a dose-escalation protocol to mitigate gastrointestinal side effects: Weeks 04: 2 mg once weekly (for groups escalating to 4 mg, 8 mg, or 12 mg) Weeks 58: 4 mg once weekly (for groups escalating to 8 mg or 12 mg) Weeks 912: 8 mg once weekly (for the 12 mg group only) Weeks 1348: Maintenance dose (4 mg, 8 mg, or 12 mg depending on group assignment) This gradual escalation reduced the incidence and severity of nausea compared to immediate initiation at higher doses

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55 Comparison to traditional antihypertensive therapies and clinical relevance Traditional antihypertensive medications, such as angiotensin-converting enzyme (ACE) inhibitors, thiazide diuretics, or calcium channel blockers, typically reduce SBP by 7 to 11 mm Hg (Table 4)