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Historically, they have been described as incretin hormones because of their effect on postprandial insulin release, but they exert effects on multiple organs beyond the pancreatic islet

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To determine the specificity of Semaglutides actions, we utilized GLP-1 receptor (GLP-1R) small interfering RNA (siRNA) to knock down the expression of GLP-1R in Ang II-stimulated cardiomyocytes

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