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This could be due to functional deficits in GLP-1 signaling caused by leptin resistance, impaired ghrelin secretion, and hyperinsulinemia associated with obesity

We also found a trend towards elevated levels of IFN in females compared to males (main effect of sex: F (1,47) = 3.211, p 2 = 0.064, p = 0.080)
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In this context, incretin mimetics that bind GLP1R resulting in suppressed downstream signaling could instead be considered an antagonist rather than an agonist

A risky medication interaction may occur
