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After randomization, treatment-emergent adverse events occurred among 56.1% of the tirzepatide 10 mg or 15 mg group, 50% of those receiving tirzepatide 5 mg and 45.1% of adults receiving placebo

In 1905, soon after the identification of secretin, administration of gastrointestinal mucosal extracts in dogs led to the discovery of an endocrine factor regulating gastric acid secretion with the proposed name gastrin [5,6]

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Caloric restriction affects serotonin and dopamine production