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Persistent high glucose levels have been linked to decreased testosterone levels, in part due to the downregulation of vascular endothelial growth factor (VEGF), which compromises testicular microcirculation, leading to Leydig cell dysfunction and blunted testosterone synthesis [64]

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Therefore, anti-inflammatory and neuroprotection effects might be exerted through inhibiting NF-B and MAPKs signaling pathways ( GLP-1 and Hypertension GLP-1 analogues LG and exendin-4 have been investigated in multiple models of hypertension