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A critical reassessment of historical failures reveals that many appetite-related peptide programs were abandoned not because their biology was flawed, but because early development conflated dose-dependent adverse effects or behavioral complexity with intrinsic target unsuitability ( The GLP-1 experience provides an instructive counterexample

Pancreatic NETs displayed the highest average level of GLP-1R staining (mean H-score of 115), whereas gNETs had the lowest level (mean H-score of 4) (Fig