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Integrating these approaches can help maximize the therapeutic benefits of GLP-1 RA therapy while minimizing GI complications

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Clinical studies and real-world evidence consistently showed that higher doses of drugs like Semaglutide and Tirzepatide led to greater reductions in body weight, which drove higher demand among both patients and prescribers

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The beneficial effects of single molecule GLP-1/Gcg coagonism were also demonstrated in ob/ob mice, which had enhanced GSIS and improved glucose tolerance upon acute treatment with a GLP-1/Gcg coagonist (Gault et al., 2013)

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