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In the SELECT trial, patients did not enroll for the specific purpose of weight loss and received standard of care covering management of CV risk factors, including medical treatment and healthy lifestyle counseling, but without a specific focus on weight loss
The gut is also the site of an important adverse reaction to metformin that often limits metformin dosing or use completely
Evan Nadler, former head of the Childhood Obesity Program at Childrens National Hospital in the District of Columbia, said in an email
