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While tirzepatide has yet to demonstrate direct cardiovascular risk outcomes in patients without type 2 diabetes, tirzepatide-treated groups did demonstrate reductions in cardiometabolic variables resulting in a significantly lower 10-year predicted ASCVD risk in patients with overweight or obesity without type 2 diabetes in post hoc analysis of the SURMOUNT-1 trial [49]

MET-233i might be best-in-class amylin, which could later be partnered with GLP-1 ( [11] ) ( [10] )

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Obesity: The impact on health, quality of life and economic wellbeing Obesity is arguably the defining health issue of the 21st Century