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Markers of inflammation, such as serum C-reactive protein (CRP), interleukin (IL)-6 and tumor necrosis factor (TNF)-, are, in fact, significantly elevated in patients with insulin resistance

Rybelsus must be taken in the morning on an empty stomach with a small amount of water, followed by a 30-minute wait before eating, drinking, or taking other medications

These physiological changes may underlie the observed reduction in HFpEF events observed in the main trial

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