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In contrast, chronic administration of GIP to obese mice [155], or short term GIP infusion within WAT of humans [156], augments adipose tissue inflammation, characterised by increased infiltration of mononuclear cells and enhanced cytokine expression

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contraindicated in patients with personal/family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2) Pancreatitis (acute inflammation presenting with severe abdominal pain) Gallbladder disease (cholecystitis or cholelithiasis) Acute kidney injury (risk increases with severe gastrointestinal adverse events causing dehydration) Diabetic retinopathy complications (for Ozempic

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