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Also, higher-protein diets have been shown to help conserve muscle mass during periods of energy restriction

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This aligns closely with the approximately 15% average weight loss seen with injectable Wegovy in earlier phase 3 trials, although the studies were not head-to-head and involved different designs and populations

4e), inguinal WAT (Fig

Clinical implications of this have been applied to patients with Prader-Willi syndrome that exhibit greatly increased circulating levels of ghrelin (20, 21)