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This increased medical attention could lead to a higher likelihood of their eye problems being detected and treated, which is what the study measured, creating the appearance of increased risk. Thirdly, the actual events were very small less than 0.2% so despite statistical adjustment results may not be accurate, he added

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Collectively these data cast doubt as to the contribution of inhibition of complex 1 as the primary target and explanation for the therapeutic effects of metformin both as an anti-diabetic and as an anti-aging drug

This may be one way to help bridge the gap in relieving symptoms