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Thats because prediabetes isnt one of the FDA-approved indications for the medication

We also detected a clear difference in GLP-1R internalisation triggered by orforglipron versus danuglipron, with the latter showing a similar level of receptor internalisation to that of exendin-4, while the former resulted in reduced receptor internalisation 5 minutes post-agonist exposure

Certain antidepressants, blood pressure meds, or hormonal treatments
