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glp-1 agonist cardiovascular outcomes and mortality with receptor agonists vs other glucose-lowering drugs in individuals with NAFLD and type 2 diabetes: a large population-based matched cohort study | Diabetologia Real-World Evidence for GLP-1 Receptor

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Exendin-4 (an endogenous insulin releasing incretin, GLP-1) reduces A accumulation and tau hyperphosphorylation in cellular and animal models of AD (85, 151, 153156)

glp-1 agonist cardiovascular outcomes and mortality with receptor agonists vs other glucose-lowering drugs in individuals with NAFLD and type 2 diabetes: a large population-based matched cohort study | Diabetologia Real-World Evidence for GLP-1 Receptor

Gastrointestinal intolerance, particularly nausea and vomiting, may affect adherence despite their tendency to diminish over time (Liu et al., 2022)

glp-1 agonist cardiovascular outcomes and mortality with receptor agonists vs other glucose-lowering drugs in individuals with NAFLD and type 2 diabetes: a large population-based matched cohort study | Diabetologia Real-World Evidence for GLP-1 Receptor

Realworld studies demonstrate high discontinuation rates of GLP1RAs by up to 75% within the first year of use, predominantly driven by side effects 20-22

glp-1 agonist cardiovascular outcomes and mortality with receptor agonists vs other glucose-lowering drugs in individuals with NAFLD and type 2 diabetes: a large population-based matched cohort study | Diabetologia Real-World Evidence for GLP-1 Receptor

Similar elimination rates of glucagon-like peptide-1 in obese type 2 diabetic patients and healthy subjects

glp-1 agonist cardiovascular outcomes and mortality with receptor agonists vs other glucose-lowering drugs in individuals with NAFLD and type 2 diabetes: a large population-based matched cohort study | Diabetologia Real-World Evidence for GLP-1 Receptor

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