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They come with risks

This effect is most pronounced during the initial weeks of therapy and may diminish over time as tolerance develops

10.1007/s00210-022-02348-7 [DOI] [PMC free article] [PubMed] [Google Scholar] Schwarz R, Hofmann B, Gergs U, Neumann J (2023) Cantharidin and sodium fluoride attenuate the negative inotropic effects of carbachol in the isolated human atrium
Doi K, Kuroshima A