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The practical answer is: optimize for muscle first, ketosis second
Medeiros and colleagues looked at how interruptions to GLP-1 medication access over the course of two years impacted weight-loss outcomes in 6,392 clients of Calibrate's online metabolic health program
Approved in 2022 for diabetes (brand Mounjaro), tirzepatide produced extraordinary results in weight loss up to ~22% in obese participants at the highest dose in a phase 3 trial ( [137] )
If your dose requires more than 1.5mL, the pool of liquid under your tongue becomes too large to maintain without swallowing
