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Oxidative stress disrupts mitochondrial membrane potential, induces mitochondrial DNA damage, and promotes the release of pro-apoptotic factors such as cytochrome c [113, 116, 120,121,122]
23,24 A post hoc analysis of the Look AHEAD trial reported that at least 10% weight loss in the first year was associated with a 21% lower risk of major adverse cardiac events
Depending on the individual factors of the womans situation, either pharmacological or surgical treatment may be most beneficial
Eng et al
