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Orlistat vs Wegovy: Key differences Medically reviewed by Dr Zoe Miller Last reviewed: 16 Oct 2025 Orlistat and Wegovy are both popular weight loss medications , but they work in very different ways to help you lose weight

"Obesity is a chronic, progressive condition that will get worse

This medication is sold in a few forms: Ozempic (injectable): approved in2017for lowering blood sugar levels in adults with type 2 diabetes, as well as reducing the risk of heart attack, stroke, or death in those with type 2 diabetes and heart disease Rybelsus (tablet): approved in2019as the first and only GLP-1 analog in pill form and indicated to improve blood sugar regulation in adults with type 2 diabetes Wegovy (injectable): approved in2021for weight management Use of Rybelsus and Ozempic for weight loss is considered However, to maintain the weight loss benefits of semaglutide, people need to continue taking it

About 5-10% of ACHD patients have PH and these patients are at a higher risk for hospitalization and death