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54,55 Central administration of GLP-1RAs suppressed appetite, accompanied by increased expression of c-Fos in neurons within the PVN, amygdala, NTS, AP, LPB and ARC, which was consistent with the results of GLP-1R expression studies in the CNS

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Botox and semaglutide operate through entirely different mechanisms, meaning there is no direct pharmacological conflict between the two treatments