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Clinicians may consider closer INR monitoring due to potential increased INR variability after GLP-1 RA initiation

The FDA has approved several GLP-1 medications including liraglutide (Victoza, Saxenda), dulaglutide (Trulicity), semaglutide (Ozempic, Wegovy, Rybelsus), and tirzepatide (Mounjaro, Zepbound)though tirzepatide is technically a dual GIP/GLP-1 receptor agonist

In conclusion, our real-world study demonstrates that the use of GLP-1 RAs may not be associated with an increased risk of mood/behavior disorders, including depression, anxiety, and suicidal behavior

At standard doses, these medications amplify that signal dramatically
