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For anti-obesity drugs to be widely adopted, they must not only demonstrate clinical efficacy but also provide a favorable costbenefit ratio compared to existing treatments

Monica Vermani, a clinical psychologist and author of A Deeper Wellness: Conquering Stress, Mood, Anxiety, and Traumas , says seven out of the nine clients she sees who take semaglutide have experienced positive effects from it, including faster progress in weight loss due to reduced cravingsand an inability to binge eat. The other two patients continued their unhealthy eating habits, but in terms of their mental health, she says none of the nine reported a loss of enthusiasm, joy or lust for life. Instead, she says, Most of them were very happy with their weight loss, after years of unsuccessful yo-yo dieting. Perhaps the best-case scenario for anyone whos taking semaglutide is to one day be able to stop taking it and maintain a trim physique, which is not out of the realm of possibility for many who are on it

Retatrutide, with triple-target effects (it works at the two receptors mentioned above and the glucagon receptor), caused people to lose about a quarter of their body weight after a year in a Phase II study (Jastreboff AM et al, N Engl J Med 2023;389(6):514526), although a follow-up study found the weight loss more in line with tirzepatide