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The authors declare that the procedures followed were in accordance with the ethical standards of the responsible human experimentation committee and in accordance with the World Medical Association and the Declaration of Helsinki

This question matters because many patients starting Ozempic or other GLP-1 therapies also maintain fitness routines involving creatine supplementation

FIGURE 1 Demographic features of included patients Before PSM, patients in the tirzepatide group (n = 6,617) were younger, with a mean age of 62.4 10.6 years, compared to those in the control group (n = 725,045), who had a mean age of 65.3 13.6 years

Lack of objective physical activity measurement and variability in dietary control are additional limitations