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Biochem Biophys Res Commun 472(1):201208 Read NW, McFarlane A, Kinsman RI, Bates TE, Blackhall NW, Farrar GB et al (1984) Effect of infusion of nutrient solutions into the ileum on gastrointestinal transit and plasma levels of neurotensin and enteroglucagon

Patient safety advice should include: Reporting severe or persistent abdominal pain immediately Maintaining adequate hydration, particularly during gastrointestinal upset Monitoring for signs of depression or suicidal ideation (regulatory authorities are monitoring this signal, though no causal link has been established) Understanding that rapid weight loss may necessitate adjustment of other medications Regarding pregnancy , advice is product-specific: Wegovy and Saxenda are contraindicated in pregnancy

Often when people gain weight, become obese or become diabetic, their levels of GLP-1 hormones go down, Burak said

Retatrutide is still in phase 3 development, and regulators would need to review full data before any authorisation decision