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Baseline characteristics The meta-analysis participants were distributed across different treatment groups: 2820 participants in the combination therapy arm and the rest divided into 37.1% (14,789 participants) SGLT-2i monotherapy, 20% (7965 participants) GLP-1RA monotherapy, and 42.9% (17077 participants) placebo or TAU

The drug is doing exactly what it was designed to do modulating reward signaling but that modulation extends beyond food to include alcohol, nicotine, and potentially other substances