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Brain food intake & body weight Liver gluconeogenesis & steatosis Muscle glucose uptake & metabolic flexibility Adipose inflammation, insulin sensitivity Preclinical results (mouse model) vs GLP-1/GIP alone: Greater body weight reduction Stronger blood glucose lowering Better insulin sensitivity Less hepatic glucose production BUT not ready for clinic: Early preclinical stage only Human safety unknown PPAR agonism has mixed CV/renal history If it translates to humans, this could redefine metabolic disease treatment beyond anything we have today

The best alternative to prescription GLP-1 for weight loss is lifestyle modification, as supplements do not effectively replicate medication

This effect might be due to direct enterocyte injury by SARS-CoV-2 or indirectly due to hyperinflammation and cytokine storm (Jung and Jung 2022)

WEIGHT-LOSS DRUGS IMPACT ON CANCER RISK REVEALED IN NEW STUDY After starting the weight-loss medications, the participants weekly average alcohol intake decreased by almost two-thirds overall from approximately 11 units of alcohol to four units after four months of treatment with the GLP-1 agonists