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Description
all studies were designed to assess noninferiority to placebo in terms of CV safety and superiority to placebo in terms of efficacy (except for REWIND, designed to evaluate superiority to placebo in terms of CV safety)

Compounded semaglutide offers the same active pharmaceutical ingredient without insurance gatekeeping

Binding of GLP-1 to GLP1R has multiple effects, including enhancing insulin secretion from pancreatic beta cells in response to glucose, increasing insulin expression, preventing beta-cell apoptosis, promoting the formation of new beta cells, reducing glucagon secretion, slowing down stomach emptying, promoting satiety, and improving glucose disposal in peripheral tissues

Side effects like nausea, constipation, or fatigue often improve with careful dose adjustment or by switching to a different GLP-1 compound
